Department of Mathematics,
University of California San Diego
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Math 218 - Seminars on Mathematics for Complex Biological Systems
Edward Stites
Salk Inst. for Biological Studies
Modeling the Biochemical Activities of Cancer Causing Mutations to Understand Why Some Patients Respond to Treatment (and Why Some Do Not)
Abstract:
The RAS protein network presents a unique situation in biology where all of the critical reactions are very well characterized both for the wild-type versions of the RAS proteins and for the cancer causing mutant forms of RAS. We have previously shown that mathematical models that build up from reaction mechanisms can be used to make non-obvious and novel predictions about the behaviors of RAS mutants. Recently, we have used these mathematical models to understand why some RAS mutations respond to drugs, when others do not.
Organizers: Li-Tien Cheng, Bo Li, and Ruth Williams
February 17, 2022
2:00 PM
https://mathweb.ucsd.edu/~bli/research/mathbiosci/MBBseminar/
Contact Bo Li at bli@math.ucsd.edu for the Zoom info
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